2021 College Football AP Poll Rankings - Week 6
| 1 | Alabama (53) | 1,541 | 1 | 5-0 |
| 2 | Georgia (9) | 1,497 | 2 | 5-0 |
| 3 | Iowa | 1,381 | 5 | 5-0 |
| 4 | Penn State | 1,360 | 4 | 5-0 |
| 5 | Cincinnati | 1,320 | 7 | 4-0 |
| 6 | Oklahoma | 1,248 | 6 | 5-0 |
| 7 | Ohio State | 1,094 | 11 | 4-1 |
| 8 | Oregon | 1,069 | 3 | 4-1 |
| 9 | Michigan | 1,053 | 14 | 5-0 |
| 10 | BYU | 990 | 13 | 5-0 |
| 11 | Michigan State | 852 | 17 | 5-0 |
| 12 | Oklahoma State | 749 | 19 | 5-0 |
| 13 | Arkansas | 745 | 8 | 4-1 |
| 14 | Notre Dame | 701 | 9 | 4-1 |
| 15 | Coastal Carolina | 694 | 16 | 5-0 |
| 16 | Kentucky | 662 | NR | 5-0 |
| 17 | Ole Miss | 601 | 12 | 3-1 |
| 18 | Auburn | 448 | 22 | 4-1 |
| 19 | Wake Forest | 412 | 24 | 5-0 |
| 20 | Florida | 343 | 10 | 3-2 |
| 21 | Texas | 303 | NR | 4-1 |
| 22 | Arizona State | 297 | NR | 4-1 |
| 23 | North Carolina State | 279 | 23 | 4-1 |
| 24 | SMU | 136 | 21 | 4-1 |
| 25 | San Diego State | 111 | NR | 4-0 |
Others receiving votes: Clemson 96, Texas A&M 41, Oregon State 27, Baylor 24, Mississippi State 18, Virginia Tech 13, Stanford 11, UTSA 10, Pittsburgh 6, Fresno State 5, Texas Tech 4, Western Michigan 3, Appalachian State 2, Kansas State 2, Boston College 1, UCLA 1
